mechanically ventilated patients
Conditions
Interventions
Deep sedation (RASS score: -5 to -3):None
light sedation (RASS score: -2 to +1):None
Sponsors
Jinling Hospital Affiliated to Nanjing University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old; 2.Patients who have received mechanical ventilation within the previous 24 hours and are expected to stay in ICU and remain ventilated for 48 hours; 3.Patients receiving sedation and analgesia.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Contraindications to sedative, analgesic drugs or their excipients; 3.Suspected or confirmed primary brain injury (traumatic brain injury, cerebral infarction, intracranial hemorrhage, hypoxic-ischemic encephalopathy, hydrocephalus, respiratory cardiac arrest, or neurological infection); 4.Patients with confirmed or suspected spinal cord injury (any part of the spinal cord injury affecting the movement of limbs), myasthenia, or other neuromuscular disease that will cause permanent or long-term myasthenia; 5.End-stage liver disease (Child-Pugh Grade C); 6.Patients with contraindications to activity (patients with deep vein thrombosis and fractures requiring immobilization); 7.Tracheotomy in 48 hours; 8.Receiving palliative care or expected to die within 48 hours; 9.History of dementia or mental illness and are taking psychotropic drugs; 10.History of drug abuse; 11.Patients who have been in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilator-free days within 28 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| New onset organ failure;New receipt of organ support therapy;Mortality;delirium;length of ICU stay;Analgesia compliance rate;Sedation compliance rate;VAP;[6]the patient's ability to move their limbs at the time of ICU exit;;Unplanned extubation;nourishment state; | — |
Countries
China
Contacts
Public ContactKe Lu
Jinling Hospital, Medical School of Nanjing University
Outcome results
None listed