Patients undergoing elective non cardiac surgery under general anesthesia and tracheal intubation
Conditions
Interventions
propofol group (group P) :During rapid sequence induction and intubation, patients receive propofol (2.0 mg/kg) as the induction agent.
ciprofol group (group C):During rapid sequence induction and intubation, patients receive ciprofol (0.4 mg/kg) as the induction agent.
Sponsors
Zhongshan Hospital (Xiamen), Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective non cardiac surgery; 2. Tracheal intubation is required for general anesthesia induction; 3. Gender is not limited, age range is 18 to 65 years old; 4. American College of Physicians (ASA) grades I-III; 5. Mallampati airway rating is I-II grade; 6. Voluntary participation, signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have respiratory infectious diseases or use hormone or bronchodilator within 2 weeks; 2. Patients predicted to have difficult airways; 3. BMI>=35kg/m^2; 4. Individuals with mental illnesses who are unable to cooperate; 5. History of allergies to opioid drugs, propofol, or cyclosporine components (i.e. soybean oil, glycerol, triglycerides, egg yolk lecithin, sodium oleate, and sodium hydroxide).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubation conditions; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of induced hypotension;Changes in heart rate during induction;Success rate of general anesthesia induction;Time for successful induction of general anesthesia;Incidence of injection pain;Mean BIS value during induction;Study the use of medication supplementation doses and/or remedial drugs.; | — |
Countries
China
Contacts
Public ContactLin Yimei
Zhongshan Hospital (Xiamen), Fudan University
Outcome results
None listed