Major Depressive disorders
Conditions
Interventions
combined iTBS and cTBS cross-sequential group:combined iTBS and cTBS cross-sequential stimulation
SNT group:10 sessions of 1800 pulse iTBS per day, treated for 5 days
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.Age 12-18; 2.meet the diagnostic criteria for depression in the 10th Revision of the International Statistical Classification of Diseases (ICD-10); 3.Total score of HAMD-17 >=17 points; 4.Right-handed; 5.The patient's physical examination, medical history, vital signs, routine blood, urine and stool, liver and kidney function, electrolyte, electrocardiogram, electroencephalogram and other indicators were normaL; 6.After fully understanding the safety of transcranial magnetic stimulation (TMS), willing to actively cooperate with the treatment, and signed by the guardian and the informed consent;
Exclusion criteria
Exclusion criteria: 1. MECT treatment within 6 months prior to enrollment; 2. Those with a history of severe physical illness and depression due to other psychoactive and non-dependent substances; 3. Patients with metallic or electronic instruments placed in their bodies, such as intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies; 4. Those at risk for seizures, with previous cranial disease, head trauma, alcoholism, EEG abnormalities, MRI evidence of structural abnormalities in the brain, or a family history of epilepsy; 5. Suicidal ideation; 6. Individuals with psychotic symptoms who require combination therapy with antipsychotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychometric measures related to cognitive behaviour;anxiety symptom, suicidal ideation, self-reported children's depression inventory;Electrophysiology and blood oxygen index; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed