Hereditary Spinocerebellar Ataxia type 3
Conditions
Interventions
rTMS stimulation group:Repetitive Transcranial Magnetic Stimulation (rTMS)
dTMS stimulation group:Deep Transcranial Magnetic Stimulation (dTMS)
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients with SCA identified by genetic testing; 2) Age: 18-75 years old; 3) Able to communicate normally and complete the scale test independently; 4) Willing to participate in this study after informed consent.
Exclusion criteria
Exclusion criteria: 1) Other familial genetic diseases, such as Parkinson's disease; 2) Other serious central nervous system diseases; 3) History of brain surgery; 4) Metallic foreign bodies or prostheses (pacemakers, insulin pumps), claustrophobia, and other contraindications to magnetic resonance (3T, 7T) examinations; 5) Failure to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| International Cooperative Ataxia Rating Scale;T1 grey structure imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebellar Cognitive Affective Syndrome Scale;Scale for the Assessment and Rating of Ataxia;Timed 25-Foot Walk;Hamilton Rating Scale for Depression;Composite Cerebellar Functional Severity Score;Digital Span;Montreal Cognitive Assessment Beijing Version, MoCA-BJ;Rest-stating MRI;Diffusion tensor imaging;Susceptibility Weighted Imaging, SWI;MRI spectroscopy Imaging;Bio-chemical indicators; | — |
Countries
China
Contacts
Public ContactChen Liu
The First Affiliated Hospital of Army Medical University
Outcome results
None listed