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Retrospective Cohort Study on the Effectiveness of Hypofractionated Radiotherapy Versus Conventional Fractionated Radiotherapy in Locally Advanced Non-Small Cell Lung Cancer with Low Tumor Mutation Burden

Retrospective Cohort Study on the Effectiveness of Hypofractionated Radiotherapy Versus Conventional Fractionated Radiotherapy in Locally Advanced Non-Small Cell Lung Cancer with Low Tumor Mutation Burden

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500095731
Enrollment
Unknown
Registered
2025-01-13
Start date
2025-01-18
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Locally advanced non-small cell lung cancer

Interventions

Hypofractionated radiotherapy:None
Conventional fractionated radiotherapy:None

Sponsors

Second Affiliated Hospital of Army Medical University of PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Patients diagnosed with non-small cell lung cancer by histopathology, and aged >=18 years; 2) Patients with radiological staging of IIIA-IIIC (eighth edition of the AJCC staging system) before radiotherapy; 3) Underwent radical intensity-modulated radiotherapy; 4) TMB<=16 mut/Mb indicated by histological or peripheral blood gene testing; 5) Have complete medical history and treatment records.

Exclusion criteria

Exclusion criteria: 1) Patients with other malignant tumors; 2) Patients who already have distant metastasis at the time of treatment.

Design outcomes

Primary

MeasureTime frame
Progression-Free-Survival, PFS;—

Secondary

MeasureTime frame
Objective response rate, ORR;Overall survival,OS;treatment-related toxicities;—

Countries

China

Contacts

Public ContactZhang Anmei

Second Affiliated Hospital of Army Medical University of PLA

8015003@qq.com+86 136 3791 5856

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026