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The Acute Effects of Coffee on Retinal and Choroidal Structure and Blood Flow in the Optic Disc and Macular Regions of Diabetic Patients Without Retinopathy and Healthy Individuals: An Assessment Using Swept-Source OCTA and Adaptive Optics SLO

The Acute Effects of Coffee on Retinal and Choroidal Structure and Blood Flow in the Optic Disc and Macular Regions of Diabetic Patients Without Retinopathy and Healthy Individuals: An Assessment Using Swept-Source OCTA and Adaptive Optics SLO.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500095722
Enrollment
Unknown
Registered
2025-01-12
Start date
2025-01-15
Completion date
Unknown
Last updated
2025-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus

Interventions

Healthy control group:Nespresso double espresso capsules
Group of diabetic patients without diabetic retinopathy:Nespresso double espresso capsules

Sponsors

Xuzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Healthy individuals, type 2 diabetic patients without retinopathy; 2. Participants aged over 18 years; 3. Able to cooperate with eye examinations; 4. Participants must have a best-corrected visual acuity of at least 20/20, axial length (AL) < 25 mm, and spherical refractive error between +3 and -3 D.

Exclusion criteria

Exclusion criteria: 1. Diabetic patients with diabetic retinopathy; 2. Uncontrolled diabetes (HbA1c > 10%); 3. Organic diseases including cardiovascular, hepatic, renal, and other systemic diseases; hypertensive patients, as well as those who cannot cooperate with OCTA and adaptive optics examinations, or those who cannot tolerate coffee; 4. History of ocular trauma, retinal laser treatments, or any ophthalmic surgeries, presence of other retinal diseases, history of glaucoma, or media opacities (such as cataracts or severe vitreous hemorrhage).

Design outcomes

Primary

MeasureTime frame
Choroidal Thickness;Retinal Vascular Density;Capillary Diameter;Choroidal Vascular Index;Intraocular pressure;—

Countries

China

Contacts

Public ContactSuyan Li

Xuzhou First People's Hospital

lisuyan1226@126.com+86 138 5210 1775

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026