sepsis
Conditions
Interventions
high dose group:The creatinine clearance rate is calculated based on the creatinine before administration, and the drug dose is recommended according to the instructions. If the daily dose of the drug
low dose group:The creatinine clearance rate is calculated based on the creatinine before administration, and the drug dose is recommended according to the instructions. If the daily dose of the drug
Sponsors
The First People's Hospital of Zhangjiagang
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with sepsis (SOFA greater than 2); (2) Age = 18 years old; (3)Patients receiving meropenem or imipenem.
Exclusion criteria
Exclusion criteria: (1) Uremia and kidney transplant patients; (2) Patients using CRRT during medication; (3) Pregnant women; (4) Patients using nephrotoxic drugs (such as intravenous glycopeptide or aminoglycoside antibacterial drugs); (5) Patients with hyperrenal function (baseline eGFR greater than 150ml/min/1.73m).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of AKI within 7 days after medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| 14-day mortality,;28-day mortality;1-year survival rate after discharge; | — |
Countries
China
Contacts
Public ContactBinbin Yu
The First People's Hospital of Zhangjiagang
Outcome results
None listed