Cervical cancer
Conditions
Interventions
Observation group (Cervical cancer patients receiving radiotherapy and using progestin):None
Control group (Cervical cancer patients who received radiation therapy but did not use progesterone):None
Sponsors
the First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in this study and sign an informed consent form; 2. Aged 18 years or older but less than 75 years; 3. ECOG performance status 0-2 and no contraindications to radiation therapy; 4. Histologically confirmed cervical adenocarcinoma, squamous cell carcinoma, or adeno-squamous cell carcinoma associated with HPV infection, without bladder or rectal affected before treatment, and initial treatment requires both external and intracavitary radiotherapy; 5. No use of estrogen or related drugs within 3 months prior to treatment; 6. No contraindications to the use of progesterone; 7. Willing to comply with the trial and follow-up procedures.
Exclusion criteria
Exclusion criteria: 1. Unknown cause of vaginal bleeding; 2. Known or suspected estrogen-dependent diseases (uterine fibroids, adenomyoma, adenomyosis, uterine sarcoma, breast cancer, etc.); 3. Contraindications to estrogen use (including recent myocardial infarction, severe hypertension, refractory diabetes mellitus, active venous or arterial thromboembolic disease in the last 6 months, decompensated hepatic disease, history of breast cancer, mammary dysplasia with atypical hyperplasia, family history of breast cancer); 4. History of local or systemic use of estrogen and related drugs in the last 3 months; 5. Suffering from acute inflammatory diseases of the genital tract, including gonorrhea, severe bacterial, fungal, trichomonas vaginitis, mycoplasma or chlamydia infections; 6. Ever having suffered a previous open vaginal injury; 7. Comorbid with vaginal ulcers or fistulas; 8. Poor compliance, not accepting the whole treatment and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of radiation vaginitis ;Incidence of vaginal stenosis;Radiation-induced bladder injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of vaginal secretions;Cleanliness of vaginal secretions;Vaginal microecology;HPV conversion rate;Radiation-induced rectal injury; | — |
Countries
China
Contacts
Public ContactRuixia Guo
the First Affiliated Hospital of Zhengzhou University
Outcome results
None listed