Cholecystectomy
Conditions
Interventions
Etomidate group:During anesthesia induction, a loading dose of etomidate at 0.2–0.4 mg/kg is administered, followed by continuous intravenous infusion of etomidate to maintain the BIS range between 40
Propofol group:During anesthesia induction, a loading dose of propofol at 1.5–2.5 mg/kg is administered, followed by continuous intravenous infusion of propofol to maintain the BIS range between 40 an
Sponsors
The Affiliated Drum Tower Hospital of Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. Scheduled for ambulatory surgery (patients who plan to stay overnight for social reasons or are unexpectedly hospitalized overnight will still be included in the study); 3. Scheduled to undergo laparoscopic cholecystectomy under general anesthesia; 4. Agrees to participate in this study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Refusal to participate in this study; 2) ASA grade III or higher; 3) BMI 29.9 kg/m²; 4) History of chronic use of analgesics or sedatives, including benzodiazepines, alcohol abuse, or allergies to etomidate or propofol; 5) History of insomnia; 6) Severe preoperative cognitive impairment with an MMSE score =180 mmHg; 10) Underwent surgery within the past 3 months; participation in another study within the past 30 days; 11) Patients who have taken steroids or other immunosuppressive drugs for more than 10 days within the past 6 months, or have a history of adrenal cortical suppression or immune system disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score on postoperative day 1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital complications (composite complications);Response time to verbal command and extubation time;PACU length of stay;Patient self-reported pain, comfort, and satisfaction with anesthesia;Injection pain;Myoclonus;Time to loss of consciousness;Incidence of hypertension and hypotension;Incidence of delirium within 24 hours postoperatively;Incidence of PONV within 24 hours postoperatively;Severity of nausea within 24 hours postoperatively;Number of vomiting episodes within 24 hours postoperatively;Pain score within 24 hours postoperatively;Sleep quality score on postoperative day 1;Intraoperative awareness;Incidence of complications within 30 days postoperatively;Readmission rate within 30 days postoperatively;Long-term quality of life at 6 and 12 months postoperatively; | — |
Countries
China
Contacts
Public ContactYao Lu
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed