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Effects of postoperative intravenous analgesia with dexmedetomidine on short-term postoperative anxiety and pain in women undergoing cesarean section

Effects of postoperative intravenous analgesia with dexmedetomidine on short-term postoperative anxiety and pain in women undergoing cesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500095695
Enrollment
Unknown
Registered
2025-01-10
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Short-term anxiety after cesarean section

Interventions

Control group:Routine allocation of postoperative patient-controlled intravenous analgesia pump: Sufentanil (2ug/kg) + Ondansetron 8mg+0.9% sodium chloride injection 100ml
Experimental group:Postoperative patient-controlled intravenous analgesia pump added with dexmedetomidine: dexmedetomidine (2ug/kg) + Sufentanil (2ug/kg) + Ondansetron 8mg+0.9% sodium chloride injecti

Sponsors

Department of Anesthesia, China-Japan Friendship Hospital, Jilin University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: (1) Singleton pregnant women; (2) gestational age: 37-42 weeks; (3) Age 18-45 years old; (4) ASA classification I-II; (5) Body mass index (BMI) =50 points).

Exclusion criteria

Exclusion criteria: (1) Allergy to dexmedetomidine; (2) Contraindications to neuraxial anesthesia such as coagulation dysfunction and shock; (3) Have a history of sedative and analgesic drug abuse or long-term use of psychotropic drugs; (4) Previous mental illness (such as schizophrenia, cognitive dysfunction, etc.) or severe liver and kidney insufficiency; (5) Have serious obstetric complications, such as uterine rupture, umbilical cord prolapse, gestational hypertension, preeclampsia and eclampsia; (6) Heart rate < 50 beats/min or abnormal cardiac conduction or rhythm, such as sick sinus syndrome; (7) preoperative hypotension (defined as systolic blood pressure <90 mm Hg); (8) Inability to communicate well.

Design outcomes

Primary

MeasureTime frame
Self-Rating Anxiety Scale Score;

Secondary

MeasureTime frame
Self-Rating Anxiety Scale Score;Visual Analog Scale;Sedation score (Ramsay score) ;Sleep quality score (subjective sleep quality score) ;The number of effective compressions of the analgesic pump and the use of salvage analgesics at 48 hours;Occurrence of nausea and vomiting;The first time of lactation after operation;Postoperative gastrointestinal recovery time;Length of postoperative hospital stay;Analgesic pump satisfaction;

Countries

China

Contacts

Public ContactZheng Yan

China-Japan Friendship Hospital, Jilin University

zheng_y@jlu.edu.cn+86 133 3168 1363

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026