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PCV-VG with driving pressure-guided ventilation on diaphragm function in diabetes patients with laparoscopic abdominal surgery : a prospective randomized controlled study

PCV-VG with driving pressure-guided ventilation on diaphragm function in diabetes patients with laparoscopic abdominal surgery : a prospective randomized controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500095689
Enrollment
Unknown
Registered
2025-01-10
Start date
2025-01-13
Completion date
Unknown
Last updated
2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaphragm weakness in diabetes patients with laparoscopic abdominal surgery

Interventions

PCV-VG (Group P):PCV-VG ventilation mode with driving pressure-guided ventilation
VCV (Group V):VCV ventilation mode with driving pressure-guided ventilation

Sponsors

The First Affiliated Hospital, Wenzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with type 2 diabetes, age>=18 years, ASA grade I-III, elective laparoscopic colorectal surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: 1.Emergency surgery or unexpected hemorrhagic shock during surgery; 2.Allergy to any of the drugs used in anesthesia; 3.History of previous thoracoabdominal surgery and trauma 4.History of severe heart, lung, liver, kidney, neurological, hematological disease or neuromuscular disorders and diaphragmatic paralysis; 5.Treatment with drugs known to affect neuromuscular function or cause drowsiness within 2 weeks before surgery; 6.Psychiatric and skin conditions that may interfere with the study protocol or potentially confound results; 7.Patients who had participated in another study within 6 month; 8.Pregnancy or breastfeeding; 9.Patients refused to participate.

Design outcomes

Primary

MeasureTime frame
Diaphragm thickening fraction during tidal breathing;—

Secondary

MeasureTime frame
Diaphragm thickening fraction during tidal breathing;Diaphragm thickness during tidal breathing;Diaphragm excursion during tidal breathing;Diaphragm thickening fraction during maximal inspiration;Diaphragm thickeness during maximal inspiration;Diaphragm excursion during maximal inspiration;Incidence of diaphragm weakness;Pulmonary parameters during mechanical ventilation (Ppeak, Pplat, Pmean, PEEP, DP, Cdyn, PETCO2, OI);arterial blood gas ;occurrence of pulmonary complications ;Incidence of postoperative hypoxemia;—

Countries

China

Contacts

Public ContactJiehao Sun

The First Affiliated Hospital, Wenzhou Medical University

sun_jiehao@126.com+86 136 7672 1930

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026