depression
Conditions
Interventions
Control group (Group C):Administer 100 ml of normal saline intravenously
VC Group (Group V):Intravenous infusion of normal saline 100 ml+VC 0.5 g
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: Diagnosed with major depressive disorder (MDD) and requiring hospitalization for MECT, age 18-59 years, with no prior serious comorbidities, American Society of Anesthesiologists (ASA) grade I-II, body mass index 18.5-30 kg/m^2, understanding and consent of the patient and/or guardian, and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Complicated with serious medical and (or) surgical diseases, such as serious cardiovascular and cerebrovascular diseases, severe hypertension, increased intracranial pressure, or the presence of intracranial electrode clips or cardiac pacemakers; 2. combined with other mental diseases such as schizophrenia; 3. Have a disease or condition that cannot complete or affect the efficacy assessment, such as cognitive dysfunction, illiteracy, mental retardation, etc.; 4. anesthesia or ECT contraindication, such as full stomach, severe decline in lung function, anesthesia allergy; 5. Allergic to anesthetics and/or VC; 6, there are VC application contraindications; 7. Patients with alcohol and drug dependence; 8, previous MECT treatment is ineffective or there are serious adverse reactions; 9. Pregnant women; 10. Participated in other clinical trials within the past 1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate after MECT treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brief Psychiatric Rating Scale (BPRS) assessment;Montreal Cognitive Assessment Scale (MoCA) assessment;24-item Hamilton Depression Rating Scale (HAMD-24) score based remission rate assessment;MECT therapeutic parameters;24-item Hamilton Depression Rating Scale (HAMD-24) score based assessement of remission rate of suicidal ideation;Perianesthetic vital signs;Anesthesia-related indices;Blood C-reactive protein (CRP) levels;Blood tumor necrosis factor (TNF-a) levels;Blood interleukin levels;Blood brain-derived neurotrophic factor (BDNF) levels;Blood ascorbic acid (VC) level; | — |
Countries
China
Contacts
Public ContactJie Luo
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed