perioperative anxiety
Conditions
Interventions
Test Group (Group A):Dexmedetomidine combined with local anesthetic nerve block
Control group (Group B):local anesthetic nerve block
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Unilateral lung mass surgery: including lobectomy/segmental resection/wedge resection;Gender, age: 18-64 years old;American Association of Anesthesiologists (ASA) Grades: I-III;Preoperative lung function report results :FEV1>=1.2L or > 40% predictive value
Exclusion criteria
Exclusion criteria: Cardiovascular and cerebrovascular disease history: such as coronary heart disease, angina pectoris, myocarditis, heart valve disease and other congenital heart disease, cerebral infarction history; A history of allergy to the drugs used in the study;There were significant neuropsychiatric disease and cognitive impairment before surgery. For patients with a significant increase in blood pressure that poses a serious risk (e.g., aortic dissection);Preoperative ECG showed heart rate (HR) > 120 beats/min;Systolic blood pressure (SBP) > 180 mmHg or diastolic blood pressure (DBP) > 110 mmHg;Abnormal liver and kidney function: Abnormal liver function is defined as aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) levels exceeding 1.5 times the upper normal limit, and abnormal kidney function is defined as serum creatinine (Cr) >= 1.5 times the upper normal limit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Anxiety and Depression Scale score;visual analogue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure; | — |
Countries
China
Contacts
Public ContactJiang Ningbin
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
Outcome results
None listed