cerebral palsy
Conditions
Interventions
Low-frequency rTMS:Low-frequency rTMS intervention and conventional rehabilitation
High-frequency rTMS:High-frequency rTMS intervention and conventional rehabilitation
Control group:conventional rehabilitation
Sponsors
Shenzhen Children's Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Meet the definition of cerebral palsy formulated in the Guidelines for the Rehabilitation of Cerebral Palsy in China (2015) compiled by the Children's Rehabilitation Committee of the Chinese Association of Rehabilitation Medicine in 2015: Cerebral palsy is a group of persistent central motor and postural development disorders and activity limitation syndrome, which are caused by non-progressive brain damage to the developing fetus or infant. Movement disorders in cerebral palsy are often accompanied by sensory, perceptual, cognitive, communicative, and behavioral disorders, as well as epilepsy and secondary musculoskeletal problems. 2. Diagnostic criteria for cerebral palsy (1) Prerequisites: 1) persistence of central movement disorders, 2) abnormal motor and postural development, 3) abnormal reflex development, 4) dystonia and muscle strength. (2) Reference conditions: 1) There is a etiological basis for cerebral palsy. 2) There may be cranial imaging evidence. The diagnosis of cerebral palsy meets the above four prerequisites. 3. According to the clinical classification formulated in the Chinese Guidelines for the Rehabilitation of Cerebral Palsy (2015), those who meet the definitions of spastic diplegia and spastic hemiplegia. (1) Spastic diplegia: the pyramidal system is mainly damaged, including cortical motor area injury. The main manifestations are increased muscle tone in all limbs, but spasticity and dysfunction in both lower limbs are heavier than in both upper limbs. (2) Spastic hemiplegia: the cone system is mainly damaged, and the clinical manifestations are increased muscle tone and motor dysfunction of one limb. 4. Other requirements (1) Age 1-6 years old; (2) Muscle tone: modified Ashworth scale grades 1-3.
Exclusion criteria
Exclusion criteria: 1. Motor Delay/Disorder Disorders: (1) Delayed Developmental Indicators/Milestones, (2) Global Developmental Delay, (3) Developmental Coordination Disorder, and (4) Autism Spectrum Disorder. 2. Spinal cord disease. 3. Diseases of the endocrine system. 4. Congenital hereditary diseases manifested as movement disorders and posture abnormalities. 5. Modified Ashworth grade 4, joint contracture, peripheral soft tissue adhesion. 6. Patients with increased intracranial pressure and epilepsy. 7. Those with mental retardation, autism spectrum disorder, and poor compliance. 8. Those who have cochlear implants, pacemakers, and other metal implants. 9. Oral anticholinergic drugs, levodopa preparations, baclophenol, ethperisone, tizanidine and benzodiazepines in the past 1 month. Botulinum toxin type A injection within the last 6 months. 10. Received selective posterior root dissection of the spinal cord and selective peripheral nerve resection. 11. Those who have a history of syncope in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Ashworth Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Tardieu scale;GMFM-88;Kinematic evoked potentials; | — |
Countries
China
Contacts
Public ContactYun Guojun
Shenzhen Children's Hospital
Outcome results
None listed