Depressive disorders
Conditions
Interventions
10-session 1800-pulse iTBS daily group:10 sessions of 1800 pulse iTBS per day, treated for 5 days
5-session 1800-pulse iTBS daily group:10 sessions of 1800 pulse iTBS per day, treated for 10 days
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1.age 12-18; 2.meet the diagnostic criteria for depression in the 10th Revision of the International Statistical Classification of Diseases (ICD-10); 3.total score of HAMD-17 >=17 points; 4.right-handed; 5.the patient's physical examination, medical history, vital signs, routine blood, urine and stool, liver and kidney function, electrolyte, electrocardiogram, electroencephalogram and other indicators were normaL; 6.after fully understanding the safety of transcranial magnetic stimulation (TMS), willing to actively cooperate with the treatment, and signed by the guardian and the informed consent;
Exclusion criteria
Exclusion criteria: 1.MECT treatment within 6 months prior to enrollment; 2.those with a history of severe physical illness and depression due to other psychoactive and non-dependent substances; 3.patients with metallic or electronic instruments placed in their bodies, such as intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies; 4.those at risk for seizures, with previous cranial disease, head trauma, alcoholism, EEG abnormalities, MRI evidence of structural abnormalities in the brain, or a family history of epilepsy,those with psychotic symptoms requiring a combination of antipsychotic medications; 5. Acute suicide; 6. Those who have psychotic symptoms and need to take antipsychotic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychometric measures related to cognitive behaviour;anxiety symptom, suicidal ideation;Electrophysiology and blood oxygen indicators; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed