acute myocardial infarction
Conditions
Interventions
Control:control 0.05mg/kg/d subcutaneous injection
Teduglutide:Teduglutide 0.05mg/kg/d subcutaneous injection
Sponsors
The first affiliated hospital of anhui medical university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-80 years old; 2.diagnosed with STEMI based on 2017ESC Guidlines for the management of acute myocardial infarction in patients presenting whith ST-segment elevation; 3.Myocardial infarction related chest pain occurred within 24 hours; 4.Wrriten informed consent was obtained form each patient upon enrollment;
Exclusion criteria
Exclusion criteria: 1.older patients (>80 years old); 2.being critically ill due to STEMI; 3.sustained ventricular tachycardia and ventricular fibrillation after STEMI; 4.patients with mechanical complications (including ventricular septal perforation, papillary muscle rupture and cardiac rupture); 5.severe cardiac shock with no reaction to vasopressors; 6.renal failure with estimated glomerular filtration<30ml/min/1.73m2; 7.acute infectious disease within 2 week before inclusion, chronic inflammatory disease, immunocompromised patients; 8.patients with neurological and psychiatric disorders; 9.patients with malignant tumors with a survival period of less than 1 year; 10.patients with liver failure; 11.patients allergic to the ingredients of the drug in this study; 12.pregnant or lactating women or women who may be considering pregnancy during the study period; 13.researchers determine any other circumstances in which patients are not suitable to participate in clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infarct size;microvascular obstruction volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiac function evaluation indicators;Major adverse cardiovascular and cerebrovascular events (MACCE events), including cardiovascular death, non fatal myocardial infarction, non fatal stroke, and ischemia driven revascularization; | — |
Countries
China
Contacts
Public ContactXie Jun
The first affiliated hospital of anhui medical university
Outcome results
None listed