Postoperative pain
Conditions
Interventions
Ropivacaine Complex Dexamethasone (10mg) Group (Group D):Ropivacaine combined with dexamethasone (10mg)
Ropivacaine Complex Dexmedetomidine (50ug) (Group R):Ropivacaine combined with dexmedetomidine (50ug)
Bupivacaine liposome group (Group B):266mg bupivacaine liposome, 20ml
Sponsors
The First People's Hospital of Hangzhou
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age 18 and above; 2.According to the American Society of Anesthesiologists (ASA) grading standards, all of them were grade I ~II; 3.Subject understands and signs informed consent;
Exclusion criteria
Exclusion criteria: 1. History of previous thoracic surgery, severe cardiovascular system disease, chronic respiratory disease (chronic obstructive pulmonary disease, asthma, interstitial lung disease and idiopathic pulmonary fibrosis), liver or kidney dysfunction, hematologic disorder or psychiatric history; 2. Known allergy to local anesthetics; 3. Local infection or systemic infection at the operation site; 4. Language barrier or communication difficulties; 5. Patient refuses to participate in the study or is unwilling to undergo regional block; 6. Patients with sensory impairments such as hyperalgesia, or other somatic pain that affects postoperative pain assessment; 7. History of chronic opioid use (more than three months or morphine equivalent more than 5mg/day for one month); 8. Patients who, in the opinion of the investigator, have any other factors that are not suitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean NRS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid (intravenous morphine/mg) and nonsteroidal anti-inflammatory drugs (NSAIDs) use;Length of stay (hours);Quality of postoperative recovery (QOR-15 scale);Adverse events; | — |
Countries
China
Contacts
Public ContactLu Xinlei
The First People's Hospital of Hangzhou
Outcome results
None listed