Postoperative cognitive dysfunction, delirium, etc., symptoms: confusion, babbling, irritability.
Conditions
Interventions
Dexmedetomidine group:administering dexmedetomidine 0.6 µg/kg by pump 10 min before chest closure
Control group :In the last 10 min before closing the chest, the corresponding dose of normal saline was infused.
Sponsors
Cangzhou Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: One hundred patients with mild cognitive impairment who underwent thoracoscopic lobectomy under general anesthesia in our hospital were selected, aged 65-5 years, with a body mass index of 18.5-23.9 kg/m2, and ASA I/II. Before the operation, had reduced memory and forgetfulness, with MoCA scores of 15-24 and MMSE scores of =27 (17-27 illiterates, 20-27 for those with =6 years of education, and 24-27 for those with >6 years education).
Exclusion criteria
Exclusion criteria: Preoperative neurodegenerative diseases that affect cognitive function (eg, vascular dementia), severe hepatic and renal insufficiency, cardiopulmonary insufficiency, history of autoimmune diseases, recent use of sedatives, antidepressants, or immunosuppressive drugs, history of head injury and alcohol abuse, visual and hearing impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of awakening: Agitation, Sedation, Shivering, Urethral catheter irritation;Postoperative cognitive function;Apolipoprotein J, IL-1B, TNF-a inflammation-related indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operation time, anesthesia time, sufentanil citrate usage, bleeding volume, fluid infusion volume; | — |
Countries
china
Contacts
Public Contactwanglei
Cangzhou Central Hospital
Outcome results
None listed