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Mechanism of low level IL-6 in reducing pregnancy outcome in patients with poor ovarian response through JAK2/STAT3 signaling pathway

Mechanism of low level IL-6 in reducing pregnancy outcome in patients with poor ovarian response through JAK2/STAT3 signaling pathway

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500095556
Enrollment
Unknown
Registered
2025-01-08
Start date
2025-01-10
Completion date
Unknown
Last updated
2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poor ovarian response

Interventions

POR-1:None
POR-2:None
POR-3:None
POR-4:None
NOR:None

Sponsors

The Affiliated Hospital of Guizhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: POR patients: Number of oocytes retrieved =5, AMH >=1.2 µg/L), POR-2: Age = 35 years, good ovarian reserve (AFC >=5, AMH>= 1.2 µg/L), POR-3: Age < 35 years, poor ovarian reserve (AFC < 5, AMH < 1.2 µg/L). POR-4: Age = 35 years, poor ovarian reserve (AFC < 5, AMH < 1.2 µg/L). Control group: Inclusion criteria 1. number of oocytes retrieved 10-15; 2. age: < 35 years old; 3. BMI < 25.0 kg/m2; 4. did not meet the subject exclusion criteria.

Exclusion criteria

Exclusion criteria: Exclusion criteria : 1. BMI > 25 kg/m2; 2. The expulsion promoting regimen is natural cycle, luteal phase expulsion promoting regimen, PPOS expulsion promoting regimen; 3. Assisted pregnancy mode: PGT; 4. Immune diseases, endometriosis, PCOS and other diseases affecting immune indicators; 5. Patients with uterine malformations; 6. Patients with recurrent miscarriage; 7. Use of growth hormone during expulsion promoting or before expulsion promoting.

Design outcomes

Primary

MeasureTime frame
interleukin-6;insulin-like growth factor 1;anti-Müllerian hormone;Fertilization rate;embryo rate;

Secondary

MeasureTime frame
two pronuclei;Clinical pregnancy;Other cytokines;antral follicle count;human chorionic gonadotropin;biochemical pregnancy rate;miscarriage pregnancy rate;miscarriage rate;

Countries

??

Contacts

Public ContactZHU HU

The Affiliated Hospital of Guizhou Medical University,

525996394@qq.com+86 175 8556 8703

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026