Infertility
Conditions
Interventions
PPOS solution group:Ovulation induction treatment using the PPOS protocol
Antagonist protocol group:Treatment with antagonist regimens for ovulation induction
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
Female
Age
35 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) female aged 35-45 years; (2) clinical diagnosis of infertility; (3) ovarian reserve function: AMH < 1.2ng/mL, AFC < 5; (4) planned to receive IVF/ICSI treatment; (5) patients voluntarily participated in the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) known to be allergic to the main ingredients or excipients of Anxinbao (recombinant human follicle stimulating hormone for injection); (2) polycystic ovary syndrome; (3) malignant tumors of hypothalamus, pituitary, ovary, uterus or breast; (4) abnormal uterine bleeding; (5) severe intrauterine adhesions, adenomyosis and other diseases affecting embryo implantation; (6) acute infection of urinary and reproductive system; (7) history of recurrent spontaneous abortion; (8) uncontrolled systemic diseases, endocrine diseases or metabolic abnormalities that affect pregnancy outcomes; (9) stage ?-? endometriosis; (10) syphilis, AIDS; (11) smoking and drinking heavily; (12) patients undergoing preimplantation genetic screening (PGS)/preimplantation genetic diagnosis (PGD); (13) other circumstances judged by the investigator as not suitable for participating in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;Cumulative pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of days that GN is used;The total amount of GN used;Blood luteinizing hormone (LH) level of HCG day;Blood estradiol (E2) level of HCG day;Early-onset LH peak;Early ovulation rate;Unavailable embryo rate;Cycle cancellation rate;Number of ovums retrieved;The number of embryos available;MII ovum Rate;2PN fertilization rate;2PN cleavage rate;High quality embryo rate;Clinical pregnancy rate in the first transplant cycle; | — |
Countries
China
Contacts
Public ContactWu Ze
The First People's Hospital of Yunnan Province
Outcome results
None listed