Sleep disorder
Conditions
Interventions
Experimental group:Start at the time of incision, intraoperative infusion of Esketamine 0.3mg/(kg.h)
Control group:The same amount of normal saline was injected during the operation
Sponsors
Longchang People's Hospital of Sichuan Province
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 65-80 years old; 2 Patients with the American Society of Anesthesiologists ASA physical status classification of I to III (where I indicates healthy patients, II indicates patients with mild systemic disease, and III indicates patients with severe systemic disease); 3. The guardian of the research subject clearly understands and voluntarily participates in the study, and the guardian of the research subject signs the informed consent form; 4. Laparoscopic surgery under general anesthesia, and the type of surgery is limited to laparoscopic cholecystectomy and laparoscopic cholecystectomy.
Exclusion criteria
Exclusion criteria: 1. Patient refuses to participate in the study; 2. Patients with mental illness, such as anxiety, depression, and schizophrenia; 3. History of recent drug abuse; 4. Take any sedative medication before surgery; 5. Preoperative Pittsburgh Sleep Quality Index (PSQI) <=5; 6. Body mass index (calculated in kilograms of weight divided by the square of height meters) above 30; 7. Cognitive dysfunction or inability to communicate (traumatic brain injury, stroke, epilepsy, Parkinson's or Alzheimer's disease, etc.); 8. Any other conditions that do not apply esketamine and are considered inappropriate by the investigator to participate in this study (emergency surgery: hypovolemia, shock, or coma; Combined anesthesia in addition to general anaesthesia is planned; infectious heart disease; coagulation abnormalities, anemia or thrombocytopenia; abnormal liver and kidney function; Those who are allergic or contraindicated to benzodiazepines, opioids, propofol, muscle relaxants and their components; Those who are judged to have difficulties in respiratory management).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sleep disorders on the first and third day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality was assessed using the Mi Band kinetograph on the 1st and 3rd day after surgery;Evaluation of postoperative VAS pain at rest and during exercise;Evaluation of anxiety and depression after surgery;Postoperative analgesic drug consumption;Postoperative complication; | — |
Countries
China
Contacts
Public ContactHang Li
Longchang People's Hospital of Sichuan Province
Outcome results
None listed