Locally advanced pancreatic cancer
Conditions
Interventions
Observation group:None
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
70 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate and sign the informed consent form; 2. Age 70-85 years old, life expectancy > 1 year. Gender is not limited; 3. ECOG physical state score=3.0 × 109/L; Absolute neutrophil count (ANC) >=1.5 × 109/L; Platelets (PLT) >=100 × 109/L; hemoglobin (Hgb) >=90 g/L; 9. Blood biochemical indexes: AST (SGOT), ALT (SGPT) <=2.5 × upper limit of normal value (ULN); Total bilirubin (TBIL) < = ULN; Serum creatinine (CRE) <=1.5 × ULN; 10. Coagulation function: prothrombin time (PT), international normalized ratio (INR) <=1.5 × ULN; 11. Able to comply with the requirements of the study visit plan and other programs. Note: ECOG score, Eastern Cooperative Oncology Group Physical Status Score.
Exclusion criteria
Exclusion criteria: 1. Accompanied by malignant tumors of other systems; 2. Received any form of anti-tumor therapy before treatment, including systemic chemotherapy, interventional chemotherapy, high-energy focused ultrasound, radiotherapy, immunotherapy, molecular targeted therapy, and anti-tumor traditional Chinese medicine therapy; 3. Have used any other non-anti-tumor research drugs within 4 weeks before treatment; 4. Combined with uncontrollable hypertension, diabetes, infection, etc.; 5. Poor compliance, unable or unwilling to sign informed consent; 6. Patients who are expected to be out of the observation period for 14 days or more during the treatment period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1-year survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival,OS;Event-free survival, EFS;Objective Response Rate,ORR;Disease control rate,DCR; | — |
Countries
China
Contacts
Public ContactWang Wenquan
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed