Helicobacter pylori infection
Conditions
Interventions
P-BQT:Amoxicillin (1000mg twice A day)+ clarithromycin (500mg twice A day)+ bismuth (220mg twice A day)+ esomeprazole (20mg twice A day) for 2 weeks
V-BQT:Amoxicillin (1000mg, twice a day)+ clarithromycin (500mg, twice a day)+ bismuth (220mg, twice a day)+ vonoprazan (20mg, once a day) for 2 weeks.
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1.Age between 18 and 70 years. 2. No use of antibiotics, bismuth, or other antimicrobial agents within 4 weeks before treatment; no use of P-CAB, PPI, H2 receptor antagonists, or other acid-suppressing drugs within 2 weeks before treatment. 3.Diagnosed as H.pylori positive by 13C or 14C urea breath test or rapid urease test. 4.Patients who are informed and agree to participate in this study, with complete medical records and follow-up data.
Exclusion criteria
Exclusion criteria: 1. Patients with serious primary diseases of the heart, lung, kidney, liver and blood system, or immunocompromised. 2. Patients with drug allergy contraindications. 3. Those with mental illness and communication disorders. 4. Pregnant and lactating women. 5. Complicated with organic lesions such as gastrointestinal tumors and gastrointestinal bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical remission;Drug sensitivity; | — |
Countries
China
Contacts
Public ContactHuang Xueping
Fujian Provincial Hospital
Outcome results
None listed