Non-acholic fatty liver disease
Conditions
Interventions
Gold Standard:Instantaneous elastic detector FibroTouch
Index test:Data obtained by instantaneous elastic ultrasound FibroTouch (CAP), liver hardness value (LSM), indocyanine green (indocyanine green) ICG clearance test data [Plasma ICG 15-minute retention
Sponsors
Kailuan General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. age: 18-75 years old; 2. history, clinical manifestations, signs, laboratory tests and other information is complete. 3. Meet the diagnostic criteria for NAFLD. 4. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1, male alcohol consumption per week >=210g, female alcohol consumption per week >=140g; 2, there are conditions that may lead to hepatic steatosis, such as the use of special drugs (tamoxifen, ethofurone, sodium valproate, methotrexate, glucocorticoids, etc.), total parenteral nutrition, inflammatory bowel disease, celiac disease, Cushing's syndrome, beta-lipoprotein deficiency, lipid atrophic diabetes, hypothyroidism, abdominal disease, and increased cortisol; 3. Patients with other liver diseases (hepatitis C virus infection, autoimmune hepatitis, hepatolenticular degeneration, etc.), malignant tumors, active infections, uremia and severe mental or cognitive impairment; 4. Pregnant or lactating women. 5, Indocyanine green (ICG) cleared the test contraindications in patients: 1) to iodine, shellfish, seafood food allergy, a history of severe allergy, anaphylactic shock. 2) Patients with uremia. 3) Patients with severe liver disease. 6. Patients with FibroTouch contraindications of instantaneous elastic detector: 1) Patients with implanted pacemaker, stent or other metal instruments. 2) Patients with ascites. 3) The skin at the test site has wound not closed. 4) Acute onset of hepatitis, cholestasis, liver edema or congestion. 5) Liver amyloidosis. 7. Unable or unwilling to sign the informed consent. 8. Other malignant diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICG-R15;ICG-K;CAP;LSM;Accuracy;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICG-R10;ICG-R5;Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactXiangming Ma
Kailuan General Hospital
Outcome results
None listed