To compare the effects of two types of anesthesia on cellular immune response in patients undergoing lower extremity orthopedic surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500095475

Enrollment

Unknown

Registered

2025-01-08

Start date

2025-01-15

Completion date

Unknown

Last updated

2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune response status of monocytes during lower extremity orthopedic surgery

Interventions

Propofol group:Propofol maintains anesthesia

Desflurane group:Desflurane maintains anesthesia.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Age: 18-65 years old; 2.ASA (American Society of Anesthesiologists Grading Standards)I-II; 3.No history of drug allergy or abnormal surgical anesthesia; 4.Healthy men, women, only lower extremity (calf, ankle) fracture patients;

Exclusion criteria

Exclusion criteria: 1.Patients with diseases of blood system and immune system; 2.Patients with metabolic diseases; 3.Patients with diseases of important organs; 4.Blurred consciousness, cognitive dysfunction; 5.People with blood clotting disorders; 6.Severe pulmonary dysfunction; 7.Unable to complete this researcher;

Design outcomes

Primary

Measure	Time frame
Changes of T lymphocyte subsets and natural killer (NK) cells in perioperative period;Peripheral arterial blood protein specific expression difference;	—

Countries

China

Contacts

Public ContactWenfei Tan

The First Affiliated Hospital of China Medical University

winfieldtan@hotmail.com+86 24 83283100

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026