Tourette's syndrome
Conditions
Interventions
Test group:rTMS
control group:Thiamethasone, Haloperidol, Acorus calamus Wind Suppressing Tablets, etc
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
7 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed (meets DSM-5 TD diagnostic criteria); 2. Age (7-18 years old), gender not limited; 3. Right-handed; 4. Disease duration>1 year; 5. Patients or their parents believe that symptoms significantly affect important areas such as social and employment activities; 6. There are no abnormalities in brain magnetic resonance imaging and electroencephalogram; 7. Patients have received stable doses of medication for at least 3 months, such as sulpiride, haloperidol, and Acorus calamus Xifeng tablets; 8. The use of medication has poor efficacy or significant side effects, and the tic symptoms have not improved for >= 2 months; 9. Patients and their legal guardian have signed informed consent;
Exclusion criteria
Exclusion criteria: 1.Not suitable for MRI scanning or not safe for rTMS experiments; 2.People with epilepsy; 3.There is a clear history of head trauma, cerebrovascular disease, convulsions, and other physical illnesses; 4.Taking drugs that can lower the threshold of seizures, such as tranquilizers and atypical antipsychotics, stimulants, tricyclic antidepressants, or bupropion; 5.History of Wilson's disease and other extravertebral diseases; 6.Other diseases assessed by our researchers as unsuitable for this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The outcome of tic disorders; | — |
Secondary
| Measure | Time frame |
|---|---|
| The outcome of tic disorders (subjective);Changes in fecal gut microbiota;Adverse reactions; | — |
Countries
China
Contacts
Public ContactJiang Chunming
Hangzhou First People's Hospital
Outcome results
None listed