Severe community-acquired pneumonia
Conditions
Interventions
Severe community-acquired pneumonia group(SCAP group):None
Community-acquired pneumonia group(CAP group):None
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >18 years old; 2. The diagnosis of CAP was in accordance with "Chinese Guidelines for the Diagnosis and treatment of adult Community-acquired pneumonia (2016 edition)". The Diagnosis of SCAP was in accordance with the "Diagnosis and Treatment of adults with Community-acquired Pneumonia. An Official Clinical" published by the ATS Association in 2019 Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. The details are as follows: (1) Diagnostic criteria of CAP: 1) Community-onset. 2) Pneumonia-related clinical manifestations: a. recent cough, expectoration, or worsening of symptoms of preexisting respiratory diseases, with or without sputum purulence, chest pain, dyspnea, and hemoptysis; b. Fever; c. signs of pulmonary consolidation and/or moist rales; d. White blood cell count > 10×10^9/L or =7.12mmol/L; f. White blood cell count < 4×10^9/L; g. Thrombocytopenia <=100×10^9/L; h. hypothermia, body temperature < 36 ° C; i. Systolic blood pressure < 90mmHg requiring aggressive fluid resuscitation.
Exclusion criteria
Exclusion criteria: 1. Long-term residence in a nursing home; 2. Patients with tracheostomy; 3. Patients with hospital-acquired infections; 4. Advanced-stage malignant tumor patients with an expected survival of less than 3 months; 5. Immunosuppressed state with concurrent infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper Respiratory Tract Pathogenology;Pulmonary Pathogenology;Peripheral Blood Mononuclear Cells; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Immune and Inflammatory Factors; | — |
Countries
China
Contacts
Public ContactHongru Li
Fujian Provincial Hospital
Outcome results
None listed