Knee Osteoarthritis (KOA)
Conditions
Interventions
Control group:Sodium hyaluronate treatment
Low dose MSC-apoVs combined with sodium hyaluronate treatment group:Low-dose MSC-apoVs combined with sodium hyaluronate treatment
High dose MSC-apoVs combined with sodium hyaluronate treatment group:High dose MSC-apoVs combined with sodium hyaluronate therapy
Sponsors
The Second People’s Hospital of Foshan
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. It meets the clinical classification criteria of KOA of the American College of Rheumatology (ACR); 2. Age =18 years old, male or female; 3.18.5kg/m2= Body mass index (BMI) =35kg/m2, male weight =50kg, female weight =45kg; 4. Knee pain =20 mm as assessed by VAS (total 100 mm); 5. Voluntarily sign the subject informed consent.
Exclusion criteria
Exclusion criteria: (1) Severe radiological knee OA with knee space stenosis of grade 3 or above as assessed by the Osteoarthritis Research Society International (OARSI) atlas; (2) Severe knee pain, the knee pain assessed by VAS (total 100 mm) =80 mm; (3) Have undergone knee surgery (arthroscopic, joint replacement, and open joint surgery) or plan to undergo knee surgery in the next 1 year; (4) A history of serious knee trauma, including arthroscopy and serious knee ligament or meniscus injury; (5) There are other types of arthritis such as rheumatoid arthritis and psoriatic arthritis; (6) Active malignant tumor or serious heart, lung, liver, kidney dysfunction; (7) Those who have a history of infection within 1 month prior to screening, require hospitalization and/or antibiotic therapy, or are currently taking systemic sex hormones (glucocorticoids), immunosuppressants, or cytotoxic therapy; (8) HIV antibody, HBsAg, HCV antibody or syphilis serological test results positive; (9) Pregnant and lactating women; (10) The investigator believes that the subjects have other conditions that are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness evaluation index;Safety evaluation index; | — |
Countries
China
Contacts
Public ContactChen Guoqiang
The Second People’s Hospital of Foshan
Outcome results
None listed