Small cell lung cancer
Conditions
Interventions
Experimental group:1. Induction treatment period:
(1) Apatinib 250mg, P.O, qd, 21 days per cycle
(2) Adebrelimab 20mg/kg or 1200mg ivgtt, d1, 21 days per cycle
(3) EC protocol: 1) Etoposide injection (E) : 100mg/m2 ivgtt for the first, second and third consecutive days, 21 days per cycle. 2) Carboplatin injection (C) : Day 1 administration, AUC=5, intravenou
One treatment cycle every 21 days.
Duration of administration: 4 cycles of induction therapy
2. Maintenance treatment period:
After completion of induction therapy, subjects continued to receive main
Sponsors
Fujian Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with extensive stage small cell lung cancer confirmed by histopathology or cytology (excluding complex small cell lung cancer); 2. Age at the time of signing the informed consent: 18-75 years old (including 18 and 75 years old), male or female; 3. The physical status of the Eastern Oncology Consortium (ECOG) was 0 or 1 (see Annex 1 for the ECOGPS scoring criteria); 4. Have not received systematic treatment for extensive small cell lung cancer; 5. Have at least one measurable lesion that meets the RECIST v1.1 standard (see Annex 3); 6. Expected survival >=3 months; 7. If the major organs function normally, the following criteria are met: 1) Blood routine test: hemoglobin (Hb) >=90g/L; Absolute neutrophil count (ANC) >=1.5×109/L; Platelet (PLT) >=100×109/L; White blood cell count (WBC) >= 3.0×109/L; 2) Biochemical examination: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =50ml/min; 3) Coagulation function: activated partial thromboplastin time (APTT), International standardized ratio (INR), prothrombin time (PT) =50%; 8. BMS must be asymptomatic or treated and stable after discontinuation of steroids and anticonvulsants for at least 1 month prior to study therapy; 9. Women of reproductive age should agree that they must use contraceptives (such as intrauterine devices [IUD], birth control pills or condoms) during the study period and for 6 months after the study ends; Have a negative serum pregnancy test within 28 days prior to study enrollment and must be a non-lactating subject; Men should be subjects who agree to use contraception during the study period and for 6 months after the end of the study period. 10. Subjects voluntarily joined the study, signed informed consent, had good compliance, and cooperated with follow-up
Exclusion criteria
Exclusion criteria: 1. Known allergy to any of the drugs in the study; 2. Previous or co-existing malignancies other than cured basal cell carcinoma of the skin, cervical carcinoma in situ, ductal carcinoma in situ of the breast (DCIS), papillary carcinoma of the thyroid gland, and other malignancies that have been adequately treated and cured for =5 years prior to the first dose with evidence of no recurrence or metastasis; 3. Presence of symptomatic or active central nervous system (CNS) metastases or cancerous meningitis (patients with asymptomatic or stable brain metastases after treatment are allowed to be included); 4. Active or previously suffering from autoimmune disease or immune deficiency; 5. In the first study, patients with clinically significant bleeding symptoms or bleeding tendency, such as hemoptysis, hematemesis, hematochezia, gastrointestinal bleeding, hemorrhagic gastric ulcer, etc., occurred within 3 months before medication; 6. Imaging (CT or MRI) shows that the tumor has invaded the large blood vessels or the boundary with the large blood vessels is unclear; Or if the investigator determines that the subject's tumor has a high risk of invading vital blood vessels during treatment and causing fatal bleeding; 7. Have high blood pressure that is not well controlled by antihypertensive medication (systolic blood pressure >= 150mmHg or diastolic blood pressure >= 100 mmHg); 8. Cardiovascular and cerebrovascular diseases of significant clinical significance: 1) Cerebrovascular accident (excluding lacunar infarction, minor cerebral ischemia, or transient ischemic attack), myocardial infarction, unstable angina pectoris, and poorly controlled arrhythmias (including QTc interval >= 450ms for men and 470 ms for women) occurred within 6 months before the first administration of the study drug (QTc interval >= 450ms for women) Fridericia formula); 2) New York Heart Association (NYHA) heart function Grade > II or left ventricular ejection fraction (LVEF) 1×104 copies /mL or >2000 IU/ml) must be excluded for a known HBV carrier; 3) Known hepatitis C virus infection (HCV) and HCV RNA positive (>1×103 copies /mL), or other hepatitis, cirrhosis; 10. Patients with uncontrolled pleural effusion, pericardial effusion or peritoneal effusion in the third space, as judged by researchers, requiring puncture and drainage; Or received ascites, pleural effusion drainage within 14 days before the first medication; 11. Patients with interstitial pneumonia or interstitial lung disease, or a history of interstitial pneumonia or interstitial lung disease requiring hormone therapy, or other pulmonary fibrosis, chronic pneumonia, pneumonia due to drug or radiation therapy, a history of congenital pneumonia, or any evidence of active pneumonia on chest CT scan that may interfere with the judgment of immune-related pulmonary toxicity; Patients with severe impairment of lung function confirmed by current pulmonary function examination; 12. Subjects who required systemic corticosteroids (> 10 mg/ day effective dose of prednisone) or other immunosuppressive agents within 14 days prior to initial dosing or during the study period. However, in the absence of active autoimmune disease, subjects were allowed to receive topical o
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective remission rate;Disease control rate;Overall survival; | — |
Countries
China
Contacts
Public ContactJinghui Lin
Fujian Cancer Hospital
Outcome results
None listed