Pulmonary complications
Conditions
Interventions
Experimental group:Mechanically ventilated inspired oxygen concentration 30%, 40%, 50%, 60%
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) elective surgery; 2) Age: >=18 years old; 3) ASA classification: level I - II; 4) Body mass index (BMI) 18-30 kg/m^2; 5) Estimated time of surgery >= 2.5 hours; 6) Radial artery puncture and central venous catheterization are required; 7) Preoperative PaO2 > 60 mmHg.
Exclusion criteria
Exclusion criteria: 1) Emergency surgery; 2) Mechanical ventilation time within 2 weeks before surgery: >1 hour; 3) concomitant COPD requiring oxygen therapy or continuous positive pressure ventilation (CPAP), history of severe or uncontrolled bronchial asthma, or history of severe restrictive lung disease; 4) acute respiratory failure (including pneumonia, acute lung injury or acute respiratory distress syndrome); 5) Involvement in thoracic surgery or history of thoracic surgery; 6) hemodynamic instability or congestive heart failure (NYHA III-IV classification or GOLD III-IV) or sustained ventricular arrhythmia; 7) sepsis or septic shock; 8) Patients with moderate to severe hepatic and renal insufficiency or those requiring renal replacement therapy (CRRT); 9) progressive neuromuscular disease; 10) Those who are pregnant or planning to have children; 11) Is participating in other clinical intervention trials; 12) Those who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2/FiO2;SpO2;Partial pressure of oxygen in alveolar air (A);Alveolar arterial oxygen differential pressure (A-aDO2);Arterial alveolar oxygen partial pressure ratio (a/A);O2Ct;SO2C oxygen saturation;Haemoglobin;Hematocrit;Oxygenated hemoglobin ratio;Carbon-oxygen-hemoglobin ratio;Methemoglobin ratio; | — |
Countries
China
Contacts
Public ContactChen Jiabao
Zhejiang Provincial People's Hospital
Outcome results
None listed