Clinical study on the effect of arousal promotion in patients with prolonged Disorders of Consciousness by atmospheric pressure pure oxygen

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500095368

Enrollment

Unknown

Registered

2025-01-06

Start date

2024-08-15

Completion date

Unknown

Last updated

2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prolonged Disorders of Consciousness

Interventions

Atmospheric Pressure Pure Oxygen Group (Experimental Group):Atmospheric Pressure Pure Oxygen

Conventional Oxygen Inhalation Group (Control Group):Conventional Oxygen

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1: Age >= 18 years old, male or female 2: The course of consciousness impairment >= 28 days 3: The revised Coma Recovery Scale score was diagnosed as VS/UWS and MCS 4: No severe liver and kidney function diseases or other diseases that may affect brain structure and function and other mental disorders

Exclusion criteria

Exclusion criteria: 1: Still in the acute stage of brain injury 2: Unstable condition 3: Incomplete medical record 4: Other conditions that, in the opinion of the investigator, cannot participate in the clinical trial

Design outcomes

Primary

Measure	Time frame
Change in CRS-R score after the end of the intervention;	—

Secondary

Measure	Time frame
Change in EEG after the end of the intervention;	—

Countries

China

Contacts

Public ContactLiu Hongxiang

Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)

snakerjnyy@163.com+86 189 1828 8873

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026