Spinal cord injury
Conditions
Interventions
Experimental group:Brain controlled closed-loop epidural electrical stimulation
Sponsors
Zhongshan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 18-65 years old (no gender requirement); 2. The clinical diagnosis is paraplegia after spinal cord injury; 3.6 months or more after spinal cord injury (spinal shock period has passed, with no significant recovery or deterioration of sensory and motor functions); 4. Injury level: T12 vertebral body level or above, with normal upper limb motor function; 5. Unable to stand or walk independently; 6. According to the American Spinal Cord Injury Association Injury Scale (ASIA), spinal cord injuries are classified as grades B, C, and D;
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. Drug or alcohol abuse; 3. Suffering from diseases that limit the motor ability of lower limbs: diabetes foot, severe osteoporosis, contracture deformity of lower limb joints, spasm, fracture (progressive/deformation due to fracture), and hospitalization due to autonomic reflex disturbance in recent 3 months; 4. Neurological disorders/injuries: traumatic brain injury, epilepsy, neurodegenerative diseases or neuropathy, severe anxiety and depression, suicidal tendencies; 5. There are surgical contraindications: infectious diseases, unstable angina pectoris, serious arrhythmia and other heart diseases; Immune system diseases and important organ diseases; Coagulation disorders and bleeding tendency; Ankylosing spondylitis and malignant tumors; Instability of the spine and narrowing of the spinal canal; 6. Unable to follow research procedures, such as language problems, cognitive impairments, psychological disorders, dementia, etc;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| American Spinal Cord Injury Association Injury Scale (ASIA) score;Muscle strength of lower limb iliopsoas and quadriceps femoris;Gravity assisted ratio required for standing; | — |
Secondary
| Measure | Time frame |
|---|---|
| The electromyographic amplitude of the iliopsoas and quadriceps muscles in the lower limbs during active exercise;Standing ability and standing time;The amplitude and latency of the sensory evoked potential; | — |
Countries
China
Contacts
Public ContactJing Ding
Zhongshan Hospital affiliated to Fudan University
Outcome results
None listed