Lodine Absorption and Metabolism
Conditions
Interventions
Control Group:Maintain the original diet, avoid eating high iodine food such as kelp seaweed, no intervention measures
High dose kelp group:Take 120 grams of kelp daily, 60 grams at lunch and 60 grams at dinner.
Slight high dose kelp group:Take 90 grams of kelp daily, 60 grams at lunch and 30 grams at dinner.
Medium dose laminaria group:Aim for 60 grams of kelp at lunch each day.
Low dose kelp group:Aim for 30 grams of kelp at lunch each day.
Sponsors
Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Body mass index: 18.5–22.9 kg/m^2; 3. Informed consent.
Exclusion criteria
Exclusion criteria: 1.History of severe diseases or undergoing treatment with therapeutic drugs; 24-hour urinary iodine levels during the washout period >300 µg/L or <100 µg/L. 2.History of thyroid diseases (including thyroid nodules or abnormal thyroid hormone levels), metabolic disorders, gastrointestinal diseases, or chronic illnesses. 3.Consumption of iodine-rich foods (e.g., seaweed, nori, ribbonfish, laver) or iodine-containing medications within one week prior to the intervention, or intake of iodine nutritional supplements/health products (e.g., multivitamins, dietary supplements) within the past month. 4.Allergic to seafood; refusal to eat seaweed; avoidance or limitation of iodine-rich foods. 5.Excessive alcohol consumption (more than 300 mL of beer, 100 mL of wine, or 30 mL of spirits per day). 6.Special dietary habits or highly irregular eating patterns. 7.No surgery within the past 6 months, no blood donation, transfusion, or significant blood loss within the past 4 months. 8.No exposure to iodine-containing X-ray/CT contrast agents within the past 6 months. 9.No use of iodine-containing skin disinfectants within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary iodine;Blood iodine;Salivary iodine;Fecal iodine;Intestinal flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Sugar;Blood lipid;Free thyroxine;Free triiodothyronine;Thyroid-stimulating hormone;Anti-thyroglobulin antibody;Anti-thyroid peroxidase antibody; | — |
Countries
China
Contacts
Public ContactYan Ma
Qingdao University
Outcome results
None listed