Alzheimers disease
Conditions
Interventions
Test group:Bilateral deep cervical lymphaticovenous anastomosis surgery
Sponsors
Harbin Medical University Affiliated Second Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) In accordance with the revised criteria for the diagnosis and staging of Alzheimer's Disease (AD) published by the National Institute on Aging and the Alzheimer's Association (NIA-AA) in 2024, patients diagnosed with AD based on biomarkers and clinical symptoms, with patients' clinical staging in the fourth to sixth stages. 2) Age between 50 years (inclusive) and 90 years (inclusive). 3) Preoperative anesthesia assessment with an ASA classification that can tolerate surgery. 4) Capable of cooperating to complete neuropsychological assessments, physical examinations, cranial MRI, PET/CT, lumbar puncture, and other medical examinations. 5) Voluntarily participate in this study, provide biological samples, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Dementia caused by other reasons: such as vascular dementia, central nervous system infections caused by AIDS and syphilis, Creutzfeldt-Jakob disease, Huntington's chorea, Parkinson's disease, Lewy body dementia, traumatic brain injury dementia, drug and alcohol poisoning and other physicochemical factors, hepatic encephalopathy and pulmonary encephalopathy and other significant somatic diseases, endocrine system disorders such as thyroid and parathyroid diseases, and dementia caused by vitamin deficiencies or any other reasons 2) Presence of congenital intellectual disabilities and severe neurological or psychiatric diseases. 3) Presence of severe underlying diseases, such as heart, liver, kidney, respiratory failure, or combined with systemic malignant tumors, etc., with an expected survival of less than one year 4) Presence of contraindications to surgery, such as coagulation disorders, allergies to surgery-related drugs, instruments, contrast agents, infections in the neck, such as skin inflammation, deep tissue infections, etc 5) Patients whose families refuse surgical treatment 6) Inability to fully cooperate with follow-up 7) Participants in other clinical trials that may affect this trial 8) Other reasons deemed inappropriate for enrollment by the investigator or sponsor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Dementia Rating (CDR) Score;Mini Mental State Examination (MMSE) Score;Montreal Cognitive Assessment (MoCA) Score;Activities of Daily Living Scale (ADL) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| PET/CT;MRI;CSF Marker Detection;Blood Marker Detection; | — |
Countries
China
Contacts
Public ContactGuo Mian
Harbin Medical University Affiliated Second Hospital
Outcome results
None listed