Intestinal ischemia/reperfusion injury after cardiopulmonary bypass
Conditions
Interventions
CPB_A group (The CPB time is less than 60 minutes.):NA
CPB_B group (The CPB time is 60-120 minutes.):NA
CPB_C group (The CPB time is more than 120 minutes.):NA
Control group (Surgery without CPB):NA
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing open-heart surgery under general anesthesia. 2.Patients age range is from 18 to 70. 3.Study participants and their families should be informed about the study and sign consent forms.
Exclusion criteria
Exclusion criteria: 1.Patients who have had acute gastrointestinal disease within the past 3 months. 2.Patients with a history of chronic gastrointestinal disease or gastrointestinal surgery. 3.Patients received potent antibiotics, either as monotherapy with third-generation cephalosporins or carbapenems, or as a combination therapy involving any mix of two or more antibiotics, both prior to surgery and within the week subsequent to the procedure. 4.The patients were diagnosed with systemic diseases before surgery, such as malignant tumor, metabolic syndrome, connective tissue disease, congenital or acquired immune deficiency disease, etc. 5.Patients had severe organ dysfunction before surgery, such as heart, lung, liver, and kidney failure, etc; 6. The patient has a history of chemotherapy and radiotherapy; 7. Pregnant and lactating women; 8. The subjects and their families did not sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FABP2;DAO;MDA;16S rRNA sequencing results of intestinal flora of patients after surgery;IL-6;IL-1ß;LDH;AST; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP;PCT;AGI Diagnosis Classification;Sequential Organ Failure Assessment;Length of Stay;Duration of Mechanical Ventilation;Duration of Mechanical Ventilation;CK; | — |
Countries
China
Contacts
Public ContactWenjun Zhou
The First Hospital of Lanzhou University,The First Clinical Medical College of Lanzhou University
Outcome results
None listed