Hypotension after induction of general anesthesia
Conditions
Interventions
Experimental group:Fluid responsiveness test was performed before induction of general anesthesia. Patients with positive fluid responsiveness were given 8ml/kg colloid supplement, and those with nega
Control group:General anesthesia was performed according to the usual procedure without additional intervention
Sponsors
Shanghai Jiaotong University School of Medicine Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=65 years old; 2. RAI-C score > 15; 3. ASA grade 1-3; 4.For patients undergoing elective surgery with preoperative gastrointestinal preparation, the expected operation time is more than 2 hours; 5. signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Venous filling ultrasound score (VExUS) >= 1 point; 2. previous history of cardiac surgery, such as coronary artery bypass grafting, valve replacement surgery, etc; 3. patients with persistent atrial fibrillation or moderate to severe valvular regurgitation or moderate to severe valvular regurgitation; 4.Patients with moderate to severe pulmonary hypertension or combined with moderate or severe pleural effusion; 5. patients with massive ascites; 6. Inability to communicate before surgery (coma, speech disorders, etc.); 7. Severe hepatic and renal dysfunction (Child-Pugh class C/ preoperative dialysis); 8. Patients with endocrine hypertension (e.g., pheochromocytoma); 9. Insufficient ultrasound window or history of allergy to ultrasound coupler; 10. History of succinylated gelatin-related allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension within 15 minutes after induction of anesthesia;Accuracy of novel non-invasive ultrasound in predicting fluid responsiveness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Doses of vasoactive drugs were used during the procedure;The incidence of vomiting within 48 hours after surgery;The number and duration of intraoperative hypotension;Incidence of postoperative adverse events;All-cause mortality at 30 days after surgery;The rate of creatinine change at 72 hours after operation;Dosage of vasoactive agents within 15 min after induction of anesthesia;Intraoperative fluid balance;Fluid balance was achieved 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactQuanhong Zhou
Shanghai Jiaotong University School of Medicine Affiliated Sixth People's Hospital
Outcome results
None listed