depression
Conditions
Interventions
Esketamine EI group:Esketamine EI group was treated with low-dose esketamine intravenous injection at anesthesia induction
Esketamine EP group:Esketamine EP group was injected with low-dose esketamine intravenous pumping during anesthesia maintenance.
Esketamine EA group:Esketamine EA group was added to the postoperative analgesic pump with low-dose esketamine.
Control group CP group:The control group was replaced with normal saline in anesthesia induction, anesthesia maintenance and postoperative analgesic pumps.
Sponsors
The Affiliated Hospital of Shandong Second Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients who undergo total knee arthroplasty for the first time, ASA grade I.-III, age 65-85 years, BMI <35kg/cm², and preoperative Hamilton Depression Rating Scale (HAMD-24) score greater than 8 points, who sign an informed consent form and agree to participate in this study.
Exclusion criteria
Exclusion criteria: Epilepsy, glaucoma, severe hypertension, intracranial hypertension, heart failure, neuropsychiatric disorders, coagulation disorders, severe liver and kidney dysfunction, allergies to this drug, taking other antidepressants, unable to cooperate with HAMD and pain scores.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety scores;Sleep quality score;Cognitive function score;Sedation score;Pain scores; | — |
Countries
China
Contacts
Public ContactSun Yingui
Shandong Second Medical University
Outcome results
None listed