Obesity
Conditions
Interventions
Group A:In this study, there were 3 rounds of trials, and each round of intervention lasted for 2 days, including the introduction day and the intervention day
Interventions were administered in a randomized crossover order, with at least 1 week of washout guaranteed between each round of intervention. The three rounds of intervention were: high-fat, multi-s
During the whole intervention period, the total amount of drinking
Sponsors
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Healthy Volunteers: 1. Age 18-29 years old; 2. Body Mass Index (BMI) between 18.5 and 23.9 kg/m2; 3. The body fat percentage of women is between 21% and 30%, and the body fat percentage of men is between 8% and 20%; 4. Blood pressure between 100/60 - 120/80mmHg; 5. Clinical biochemical examination (blood routine, blood glucose, blood lipids, liver function, renal function, endocrine system function, digestive system function, electrolyte balance) showed no abnormality. 6. Willing to maintain a daily lifestyle as required during the intervention period, avoiding extreme diet, high-intensity exercise, and irregular work and rest 7. Understand and sign the informed consent form, be willing to cooperate with the intervention process, and complete all the trial contents Overweight or obese volunteers: 1. Age 18 - 65 years old; 2. BMI >=24 kg/m2; 3. Blood pressure between 100/60 - 130/80mmHg; 4. C-reactive protein (CRP) is between 1 and 10 mg/L. 5. Willing to maintain a daily lifestyle as required during the intervention period, avoiding extreme diet, high-intensity exercise, and irregular work and rest; 6. Understand and sign the informed consent form, be willing to cooperate with the intervention process, and complete all the trial contents
Exclusion criteria
Exclusion criteria: 1. Use of nutritional supplements in the preceding 3 months. 2. Use of medications likely to interfere with food metabolism in the preceding 3 months. 3. Allergy to study agents. 4. Former or current smoker. 5. Excess alcohol intake. 6. Weekly exercise time 480 minutes. 7. Acute or chronic insomnia or sleep disorders. 8. Irregular circadian rhythms. 9. Chronic calorie restriction or excess. 10. Habitual intake of coffee (>=1 cup/day); 11. Weight change of =3kg during the past 1 month. 12. Dietary requirements. 13. Difficulty with venous blood collection. 14. Significant anemia during the past 3 months or hemoglobin <130g/L (male) and <120g/L (female). 15. Blood donation within the last 1 month. 16. Pregnant or lactating (female). 17. History of previous surgeries involving the digestive tract or other major organs such as the heart, lungs, liver, spleen, and kidneys. 18. Digestive system diseases that affect food digestion and absorption. 19. Abnormal liver function. 20. Abnormal kidney function. 21. Endocrine diseases affecting the metabolic system. 22. Cardiovascular diseases. 23. Diseases of the urinary system. 24. Cancers. 25. Infectious diseases. 26. Psychiatric disorders. 27. Non-cognitive ability. 28. Currently participating or has participated in clinical studies other than this project within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal microbiota; | — |
Countries
China
Contacts
Public ContactGeng Zong
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Outcome results
None listed