Gram-positive bacterial infection
Conditions
Interventions
Prospective data group:None
Sparse collection group:None
Sponsors
The Affiliated Suzhou Hospital of Nanjing University medical school, Suzhou Scicence & Technology Town Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. postoperative neurosurgical patients aged =18 years; 2. Linezolid regimen = 3 days; 3. linezolid dosing regimen: 0.6g, q12h, intravenous drip; 4. Gram-positive bacterial infection.
Exclusion criteria
Exclusion criteria: 1. patients who were transferred to another hospital during the administration of the drug with incomplete data; 2. continued renal replacement therapy or hemodialysis or extracorporeal membrane oxygenation during linezolid treatment; 3. baseline platelet count < 75 x 10^9/L; 4. concomitant disseminated intravascular coagulation or other bleeding disorders; 5. concomitant use of antiplatelet agents or heparin; 6. severe hepatic impairment; 7 Incomplete or missing clinical and laboratory information for patients before and after linezolid treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration;Cerebrospinal Fluid concentration;Leukocyte;Neutrohil;C-Reactive Protein;Procalcitonin;Clinical symtoms;Age;Gender;Weight;Renal function;Liver function;Urine volume;CSF cell count;CSF glucose;CSF protein;Cerebrospinal fluid drainage;Total bilirubin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin; | — |
Countries
China
Contacts
Public ContactZhang Ying
The Affiliated Suzhou Hospital of Nanjing University medical school, Suzhou Scicence & Technology Town Hospital
Outcome results
None listed