Diversity and composition of the lung microbiome changes after one-lung ventilation during thoracoscopic lobectomy

Diversity and composition of the lung microbiome changes after one-lung ventilation during thoracoscopic lobectomy - Diversity and composition of the lung microbiome changes after one-lung ventilation during thoracoscopic lobectomy

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500095243

Enrollment

Unknown

Registered

2025-01-03

Start date

2024-04-30

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative lung injury

Interventions

IR:One lung ventilation

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with lung cancer before surgery in our hospital and plan to undergo thoracoscopic lobectomy under general anesthesia. 2. Age 18-70 years old; 3. American Society of Anesthesiologists (ASA) grade I.~III.; 4. The estimated operation time is > 1 hour

Exclusion criteria

Exclusion criteria: 1. Acute lung injury before surgery; 2. Inability to obtain informed consent; 3. Respiratory distress syndrome and respiratory failure within three months before surgery; 4. Preoperative failure of liver, kidney, heart and other organs; 5. Previous lung surgery; 6. Preoperative pulmonary function test for extremely severe obstructive or restrictive disease 7. Pregnancy status

Design outcomes

Primary

Measure	Time frame
Pulmonary flora diversity;	—

Secondary

Measure	Time frame
Inflammatory factor;	—

Countries

China

Contacts

Public ContactQu Liangchao

The First Affiliated Hospital of Nanchang University

ferry7@163.com+86 180 7012 8651

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026