Alzheimer's disease
Conditions
Interventions
Gold Standard:The first step is to identify cognitive impairment, which is the prerequisite for the diagnosis of AD. The second step is to rule out non-AD induced cognitive impairment through auxiliar
Index test:Produ
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Age 50 to 90 (including 50 years old and 90 years old), gender is not limited; 2) The subjects have primary school education or above or equivalent ability, and are able to complete the cognitive ability measurement and other tests stipulated in the program; 3) Can provide 4ml of blood; 4) For voluntary participation, if the subject cannot sign the informed consent in person due to limited cognitive ability or other reasons, the subject is allowed to leave the signature blank and explain the reason. The legal guardian shall sign the reason explanation, and the legal guardian shall sign the informed consent. 5) If AD subjects are enrolled, the following conditions should also be met: a) memory loss of at least 12 months; b) Patients with cognitive impairment determined by MMSE (the criteria for patients with mild, moderate or severe disease were determined by Clinical Dementia Degree Scale (CDR), 0.5-1: mild; 2: moderate; 3: heavy); c) Hajinsky Ischemia Scale (HIS) total score <=4 points; d) Hamilton Depression Scale (17-item edition) total score<=7; e)He was clinically diagnosed as an AD patient.
Exclusion criteria
Exclusion criteria: 1) Subjects deemed unsuitable for participation in this experiment by the investigator based on professional knowledge; 2)MMSE score=3. d) Have suffered from cerebrovascular, epilepsy, Parkinson's disease and other central nervous system diseases; e) People who have suffered from psychotic disorders such as bipolar disorder, major depression or delirium; f) The presence of uncorrectable visual and hearing disorders and inability to complete neuropsychological tests and scales; g) Memory impairment and related symptoms that can be explained by other diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relative expression of Transient receptor potential canonical 6;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactChunjiu Zhong
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed