Colorectal disease
Conditions
Interventions
A Group (Remimazolam):Induction: Sufentanil 0.1 µg/kg + Remimazolam 0.15-0.25 mg/kg. Maintenance: Remimazolam 0.5-1.5mg/kg/h. Reversal: Flumazenil (0.5mg) ,naloxone (0.3ug/kg)
B Group (Propofol):Induction: Sufentanil 0.1 µg/kg + Propofol 1.5-2.5 mg/kg. Maintenance: Propofol 4-8mg/kg/h. Reversal: Naloxone (0.3ug/kg)
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age older than 65 years; 2.Body Mass Index (BMI) from 18.5 to 30 kg/m²; 3.Patients receiving elective colonoscopy treatment (Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Colorectal polypectomy), with a surgical duration more than 30 minutes. 4.American Society of Anesthesiologists (ASA) classification I to III; 5.Voluntarily participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Subjects refuse to participate in this study; 2.History of severe cardiovascular, neurological, respiratory, liver, kidney, and metabolic disorders; 3.History of abnormal recovery from anesthesia; 4.Heart rate 180mmHg and/or DBP > 110mmHg) or hypotension (BP < 90/60 mmHg) 7.Patients with neuromuscular disorders or mental disorders; 8.History of analgesics or tranquilizers abuse; 9.Other occasions when the investigators determined inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The postoperative quality of recovery-15 scale (QoR-15); | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs at different times ( blood pressure, heart rate, oxygen saturation [ SpO2 ], prtial pressure of end tidal carbon dioxide [PetCO2], respiration rate, [RR]);Time required from anesthesia to laryngeal mask airway(LMA) insertion ;Time required from LMA insertion to the start of operation;Duration of the operation;Recovery time;Duration from the removal of the LMA to leaving operating room.;Time in postanesthesia care unit(PACU);Modified Observer's Alertness/Sedation(MOAA/S) scale;Body motion grade;Frequency of intestinal motility;Total use of propofol;Total use of remimazolam;The rate of hypotension;The incidence of low oxygen saturation;The incidence of bradycardia, or tachycardia;The frequency and dosage of vasopressor administration during the operation;The frequency and dosage of atropine administration during the operation;Satisfaction evaluation (visual analogue scale,VAS);The rate of adverse reactions (nausea, vomiting, dizziness, abdominal distension, drowsiness, throat pain, and jaw discomfort);The incidence of postoperative delirium;Total duration of mechanical ventilation;The postoperative quality of recovery-15 scale (QoR-15); | — |
Countries
China
Contacts
Public ContactGuo Ruijuan
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed