None
Conditions
Interventions
Group A:Intertransverse process block with 0.3 ml/kg of ropivacaine 0.375%
Group B:Intertransverse process block with 0.4 ml/kg of ropivacaine 0.375%
Group C:Intertransverse process block with 0.5 ml/kg of ropivacaine 0.375%
Sponsors
The First Affiliated Hospital of Gannan Medical University, China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1)American Society of Anesthesiologist physical status Classification I-III; (2)Patients aged 18-75 years old who plan to elective thoracoscopic lobectomy/segmental lung resection at our hospital; (3)Agree to participate in the study and be able to understand the relevant assessment content; (4)Height 145-175 cm; (5)BMI 18.5-28 kg/m^2 .
Exclusion criteria
Exclusion criteria: (1) Contraindications to regional nerve block, including but not limited to abnormal coagulation function, skin infection at the block site, and allergy to local anesthetic drugs; (2) Presence of severe organ dysfunction, including but not limited to renal dysfunction (creatinine >442umol/L or renal replacement therapy), hepatic dysfunction (Child-Pugh class C), central or peripheral system diseases and other severe cardiopulmonary diseases; (3) History of chronic pain, those taking opioids, hormones or non-steroidal drugs for a long period of time; (4) Patients who have participated in other studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypotension (hypotension defined as MAP<65mmHg or blood pressure drop of more than 30% from baseline for more than 1 minute); | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin sensory block segment 20min after completion of block;Blood pressure and heart rate at different time points;The occurrence of hypotension at different time during operation;Intraoperative blood gas analysis at different time points (before induction of anesthesia, 1 h into surgery, at the end of surgery);Total intraoperative and postoperative opioid use;Total norepinephrine dosage and duration of use;Duration of surgery;Intraoperative infusion volume;Intraoperative bleeding;RASS scores at different postoperative time points (5 min postoperatively, 10 min postoperatively, 15 min postoperatively, 20 min postoperatively, 25 min postoperatively, 30 min postoperatively);Incidence of agitation during awakening;Postoperative tracheal tube removal time;Anesthesia recovery time;VAS scores of rest and activity at different time points after surgery (2h, 4h, 8h, 12h, 24h, 48h);The time of first PCA and the number of rescue analgesia in 48h after surgery;Rehabilitation quality scores before surgery and 24 and 48 hours after surgery (QoR-15);Postoperative nausea and vomiting, puncture site infection, itching and other adverse events;Postoperative drain removal time;time to first ambulation after surgery;time to diet after surgery;time to exhaust after surgery; | — |
Countries
China
Contacts
Public ContactZhan Lifang
The First Affiliated Hospital of Gannan Medical University
Outcome results
None listed