femoral neck fracture
Conditions
Interventions
Control group (Group C):Patients in group C were given intravenous injection of propofol 1-1.5 mg/kg, etomidate 0.15-0.2mg/kg, midazolam 0.04-0.05mg/kg, sufentanil 0.4-0.5µg/kg, and rocuronium 0.6-0.7
Experimental group (Group OF):Patients in group OF were given intravenous injection of propofol 1-1.5 mg/kg, etomidate 0.15-0.2mg/kg, midazolam 0.04-0.05mg/kg, esketamine 0.4-0.5mg/kg, and rocuronium
Sponsors
The First Affiliated Hospital of Gannan Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who met the indications of total hip arthroplasty and were informed about the study and signed the informed consent form were selected; 2. Age 60-80 years old; 3. ASA grade ?-?; 4, can speak Mandarin, communication barrier; 5. There were no obvious abnormalities in heart, lung, liver and kidney function
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this research; 2. Complicated with important organ dysfunction; 3. Patients with severe hypertension and diabetes mellitus; 4. Those who are allergic to the test drugs; 5. Patients with severe bradycardia and conduction block; 6. Patients with chronic pain, mental illness, or history of alcohol or drug abuse who were unable to cooperate with the trial; 7. Long-term use of sedative or analgesic drugs; 8. Increased intracranial pressure or intraocular pressure;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of opioid-related adverse reactions within 24h after surgery;Incidence of opioid-related adverse reactions within 48h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of perioperative bradycardia ;Incidence of perioperative hypotension;Perioperative heart rate;Perioperative blood pressure (SBP, DBP, MAP);Length of PACU stay;Time of tracheal extubation;VAS scores of pain at rest and during movement at 6h after surgery were recorded;VAS scores of pain at rest and during movement at 12h after surgery were recorded;VAS scores of pain at rest and during movement at 24h after surgery were recorded;VAS scores of pain at rest and during movement at 48h after surgery were recorded;The scores of QoR-15 scale at 24h after surgery were recorded;The scores of QoR-15 scale at 48h after surgery were recorded;The number of PCIA compressions within 24h after surgery was recorded;The number of PCIA compressions within 48h after surgery was recorded;The use of additional analgesics within 24h after surgery was recorded;The use of additional analgesics within 48h after surgery was recorded;Patient satisfaction with anesthesia 24h after surgery(including satisfaction and dissatisfaction); | — |
Countries
China
Contacts
Public ContactLifeng Wang
The First Affiliated Hospital of Gannan Medical University
Outcome results
None listed