frail
Conditions
Interventions
Remimazolam Tosylate Group:Anesthesia induction with an intravenous injection of remimazolam tosylate at 0.2 mg/kg
Etomidate Group:Anesthesia induction with an intravenous injection of etomidate at 0.3 mg/kg
Sponsors
Fuyang People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 82 Years
Inclusion criteria
Inclusion criteria: (1) No gender restriction; (2) Age >= 65 years; (3) Body mass index (BMI) 18-28 kg/m²; (4) American Society of Anesthesiologists (ASA) physical status classification II-III; (5) FRAIL scale (fatigue, resistance, ambulation, illness, and loss of weight index) score 3-5.
Exclusion criteria
Exclusion criteria: (1) Patients admitted via emergency; (2) Presence of severe cardiovascular dysfunction (acute heart failure, myocardial infarction, etc.) or severe hypertension; (3) Presence of myasthenia gravis or psychiatric disorders; (4) History of liver or kidney dysfunction; (5) Allergies or contraindications to benzodiazepines, opioids, or etomidate; (6) History of alcohol abuse; (7) Long-term use of sedatives or psychotropic medications; (8) History of adrenal insufficiency; (9) Anticipated difficult airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve (AUC) of mean arterial pressure (MAP) below (AUCMAP-) or above (AUCMAP+) the baseline value within 10 minutes after the start of anesthesia induction in both groups;The area under the curve (AUC) of heart rate (HR) below (AUCHR-) or above (AUCHR+) 10% of the baseline value within 10 minutes after the start of anesthesia induction in both groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Loss of consciousness time (the time from the initiation of anesthesia to the disappearance of the corneal reflex);The time from the initiation of anesthesia induction to the BIS (Bispectral Index) < 60;The incidence of drug adverse reactions (including injection pain, myoclonus, etc.);The incidence of cardiovascular adverse events (including newly developed malignant arrhythmias, acute heart failure, non-fatal myocardial infarction, non-fatal stroke, and cardiogenic death, etc.);The use of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactQiufeng Wang
Fuyang People's Hospital
Outcome results
None listed