Insomnia Disorder, ID
Conditions
Interventions
Dex nasal spray treatment group:Dexmedetomidine nasal spray treatment
SGB treatment group:Stellate ganglion block therapy
Dex nasal spray + SGB combined treatment group:Combined dexmedetomidine nasal spray and stellate ganglion block therapy
Sponsors
Henan Provincial People's Hospita,medical
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Met the diagnostic criteria for ID and had repeated episodes that could not be alleviated by medication, physiotherapy or cognitive behavioral therapy; 2. Meet the dual criteria of subjective scale and objective PSG diagnostic ID, and the scale score requires PSQI>=7 points; 3. Age 18-60 years old; 4. Primary school education or above; 5. MRI routine brain examination was normal; 6. Right-handed.
Exclusion criteria
Exclusion criteria: 1. Insomnia caused by sleep disorders, such as obstructive sleep apnea syndrome, sleep periodic limb movement, etc; 2. Severe suicidal ideation, severe mental disorder; 3. Have or currently have a history of tobacco, alcohol and drug abuse; 4. bradycardiac arrhythmia; 5. Pregnancy; 6. Taking antibiotics for more than 3 days within 1 month; 7. MRI contraindications; 8. Claustrophobia; 9. History of mental and neurological diseases and head trauma; 10. Hereditary diseases in the family; 11. History of major physical illness; 12. Severe rhinitis, nasal deformity; 13. People who are allergic to narcotic drugs such as dexmedetomidine, midazolam or lidocaine;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Calculation and Statistical Analysis of Brain Function Indicators for Resting State Data;Sleep efficiency and sleep composition;Subjective sleep status; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function, kidney function;5-hydroxytryptamine (5-HT), gamma aminobutyric acid (GABA), norepinephrine (NA), dopamine (DA); | — |
Countries
China
Contacts
Public ContactYongli Li
Henan Provincial People's Hospita,medical
Outcome results
None listed