Skin aging
Conditions
Interventions
Experimental group:Thermage+Anti-wrinkle cream
Control group:Thermage + Moisturizing Cream
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
Female
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 40 years old or above but less than 65 years old, healthy females with no history of major illnesses in the cardiovascular system, digestive system, endocrine system, immune system, nervous system, etc., and no history of mental or psychological disorders. 2.No severe acne on the face. 3.Meet the indications for Thermage facial treatment and be able to tolerate discomfort during the treatment process. 4.Fitzpatrick Scale II to IV; 5.Mild to severe nasolabial folds with a difference in severity between the two sides of =1 point on the scale. 6.Mild to severe upper facial sagging, with a difference in severity between the two sides of =1 point on the scale. 7.Mild to severe jawline sagging, with a difference in severity between the two sides of =1 point on the scale. 8.Mild to severe forehead wrinkles, crow's feet, laugh lines, uneven skin tone, rough skin texture, and dullness, with a difference in severity between the two sides of =1 point on the scale. 9.Mild to severe eyebrow ptosis, with a difference in severity between the two sides of =1 point on the scale. 10.Subjects who are willing to read and sign the informed consent form, as well as the statement allowing image acquisition and related information authorization. 11.Able to undergo treatment, data collection, and cooperate with visits as required by the study. 12.The subject agrees not to significantly alter their lifestyle, including diet and exercise habits, throughout the duration of the study. 13.The subject has not undergone any medical aesthetic treatments in the past 6 months and agrees not to undergo any medical aesthetic treatments during the entire study period. 14.The subject agrees to use only the skin care products provided by the sponsor throughout the study period, refrain from using any other skin care products, and not to undergo any beauty treatments at a beauty salon. 15.The subject agrees to strictly adhere to sun protection measures throughout the study period, such as wearing sunglasses, hats, using umbrellas, and wearing masks. 16.The subject agrees to keep a daily record of the product usage process and submit photographs of the product usage process to the trial personnel for inspection. 17.The subject has not participated in any clinical studies within the past month and agrees not to participate in any clinical studies during the entire study period.
Exclusion criteria
Exclusion criteria: 1. Pregnant, lactating women, subjects who have changed, started or stopped oral contraceptives or any hormonal therapy within 1.5 months prior to the start of the study; 2. Those who have metal, pacemaker or other similar electronic devices implanted in the body; 3. Patients with active skin diseases, skin infections, skin tumors, history of obvious chloasma, psoriasis, rosacea, seborrheic dermatitis, and severe psoriasis; 4. Subject is currently taking or routinely taking systemic or topical corticosteroids, vasoconstrictors, antibiotics, and anti-inflammatory drugs within 2 weeks prior to the start of the study; 5. Subject has a history of acute or chronic skin disease, medical and/or physical disease (such as skin cancer, diabetes, asthma, hypertension, hyperthyroidism or hypothyroidism); 6. History of allergies to drugs and cosmetics; 7. Those who have a clear history of sun exposure, photoelectric therapy, chemical peel treatment within 1 month, or cannot strictly protect the sun after treatment; 8. Subjects who regularly engage in outdoor activities (such as sunbathing, outdoor work); 9. There are other factors that affect the observation of efficacy; 10. Any employee of a cosmetics company and an employee of Shanghai Spectrum Testing Technology Co., Ltd.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physician Rating (Nasolabial Fold); | — |
Secondary
| Measure | Time frame |
|---|---|
| Physician Rating (Forehead Lines, Crow's Feet, Laugh Lines, Jawline, Upper Facial Sagging, Eyebrow Drooping, Skin Roughness, Skin Tone Evenness, Skin Glossiness);Safety Evaluation Indicators (Adverse Reactions such as Erythema, Pigmentation, Edema, Dryness, Erythematous Rash, etc.);Skin Hydration Level;Transepidermal Water Loss (TEWL);Skin Color;Facial Volume;Dermal Thickness;Dermal Density;Overall Facial Photography;Skin Hyperspectral Imaging;Two-Photon Microscopy Images;Wrinkle 3D Imaging System;Subject Self-Assessment; | — |
Countries
China
Contacts
Public ContactDong Jiying
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed