Clinical Observation of Esketamine Hydrochloride Combined with Propofol for Opioid-Free Anesthesia in Pediatric Strabismus Surgery

Clinical Observation of Opioid-Free Anesthesia in Daycase Pediatric Strabismus Surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500095136

Enrollment

Unknown

Registered

2025-01-02

Start date

2024-01-17

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pediatric Strabismus Surgery

Interventions

Control group:Routine general anesthesia

Observation group:opioid free anesthesia

Eligibility

Sex/Gender

All

Age

3 Years to 12 Years

Inclusion criteria

Inclusion criteria: ASA grade ? or ?, age 3-12 years old

Exclusion criteria

Exclusion criteria: Contraindications of escitalopram, cyclophosphamide and dexmedetomidine; Upper respiratory tract infection one week before operation; History of taking sedative and analgesic drugs; Congenital diseases such as epilepsy and asthma; Refuse to sign informed consent; Abnormalities cardiopulmonary, liver and kidney functions.

Design outcomes

Primary

Measure	Time frame
Hemodynamic parameters, MAP, HR;	—

Secondary

Measure	Time frame
the pediatric anesthesia emergence delirium scale,PAED;Face, Legs, Activity, Crying, Consolability;Perioperative adverse reactions;Richmond Agitation-Sedation Scale;Sleep Disturbance Scale for Children;Rescue analgesic sedation dose;Recovery time;stay time of PACU;Extubation time;	—

Countries

China

Contacts

Public ContactZhentao Sun

The First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province

2815768680@qq.com+86 136 0345 5483

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026