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The modified Dixon sequential method was used to determine the effective dose of oliceridine fumarate injection combined with propofol to inhibit intraoperative kinematic response in hysteroscopy

The modified Dixon sequential method was used to determine the effective dose of oliceridine fumarate injection combined with propofol to inhibit intraoperative kinematic response in hysteroscopy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500095126
Enrollment
Unknown
Registered
2025-01-02
Start date
2025-01-15
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecological diseases

Interventions

The group with no history of vaginal delivery:Oliceridine combined with propofol
The group with history of vaginal delivery:Oliceridine combined with propofol

Sponsors

Shaanxi 215 Hospital of nuclear industry
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1.Female; 2.18~64 years old; 3.BMI:18.5~29.9 kg/m²; 4.ASA level I~II; 5.Patients diagnosed by a gynecologist as requiring hysteroscopy;

Exclusion criteria

Exclusion criteria: 1.Patients with a history of severe heart, brain, lung, liver, kidney, endocrine diseases and psychiatric-related diseases; 2.Heart rate< 50 beats per minute; 3.History of acute respiratory infection that has not been cured within 14 days, significant difficulty in the airway; 4.Patients with known hypersensitivity to propofol, oliceridine and their components; 5.Alcoholism, long-term use of sedatives or analgesics; 6.Patients with special hysteroscopic treatments.

Design outcomes

Primary

MeasureTime frame
Effective dose of oliceridine fumarate injection;

Secondary

MeasureTime frame
baseline;vital signs;Adverse reactions;numerical rating scale scores;Propofol starting dose;Total dose of propofol;The amount of vasoactive drug used;Duration of surgery;

Countries

China

Contacts

Public ContactLiuqin Jiang

Shaanxi 215 Hospital of nuclear industry

jlq215hp@163.com+86 29 32088348

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 19, 2026