Hip and knee replacement
Conditions
Interventions
Tranexamic acid group:Intravenous tranexamic acid 1g was given 30min before operation
control group:Isovolumic saline
Sponsors
Tai 'an Central Hospital (Tai 'an Central Hospital affiliated to Qingdao University)
Taishan Medical Center)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=65 years old; 2. Normal coagulation function before operation;3. There was no abnormality in preoperative color Doppler ultrasound of lower limbs; 4.There was no obvious damage of liver and kidney function before operation.
Exclusion criteria
Exclusion criteria: 1. Previous occurrence of deep vein thrombosis (including the history of intermuscular vein thrombosis), cerebral embolism and cerebral infarction;2.Clear TXA allergy and contraindications; 3.Patients with high risk of thrombosis, including atrial fibrillation, after pacemaker implantation and after stent implantation; 4. Severe hepatic and renal insufficiency; 5.Long-term oral administration of antiplatelet drugs such as aspirin and clopidogrel and anticoagulant drugs such as warfarin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total blood loss,blood transfusion and transfusion rate;Incidence of early postoperative cognitive impairment;Incidence of postoperative deep venous thrombosis; | — |
Countries
China
Contacts
Public ContactWei Ren
Tai 'an Central Hospital (Tai 'an Central Hospital affiliated to Qingdao University) Taishan Medical Center)
Outcome results
None listed